A NOVEL, CONVENIENT, 3-DIMENSIONAL ORTHOGONAL STRATEGY FOR SOLID-PHASE SYNTHESIS OF CYCLIC-PEPTIDES

被引：232

作者：

KATES, SA

SOLE, NA

JOHNSON, CR

HUDSON, D

BARANY, G

ALBERICIO, F

机构：

[1] MILLIPORE CORP,75A WIGGINS AVE,BEDFORD,MA 01730

[2] ARRIS PHARMACEUT CORP,S SAN FRANCISCO,CA 94080

[3] UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 10期

关键词：

ALLYL ESTERS; CYCLIC PEPTIDES; ORTHOGONAL PROTECTION; PSEUDO-DILUTION; SOLID-PHASE SYNTHESIS;

D O I：

10.1016/0040-4039(93)85003-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Head-to-tail cyclic peptides are made by an efficient three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl), featuring side-chain anchoring to PAC or PAL supports, selective palladium (0)-catalyzed allyl removal, and resin-bound cyclization mediated by BOP/HOBt/DIEA.

引用

页码：1549 / 1552

页数：4

共 43 条

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[10] CYCLIC-PEPTIDES - PAST, PRESENT, AND FUTURE
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