(6S)-6-FLUOROSHIKIMIC ACID, AN ANTIBACTERIAL AGENT ACTING ON THE AROMATIC BIOSYNTHETIC-PATHWAY

被引：111

作者：

DAVIES, GM ^{[1
]}

BARRETTBEE, KJ ^{[1
]}

JUDE, DA ^{[1
]}

LEHAN, M ^{[1
]}

NICHOLS, WW ^{[1
]}

PINDER, PE ^{[1
]}

THAIN, JL ^{[1
]}

WATKINS, WJ ^{[1
]}

WILSON, RG ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,DEPT INFECT RES,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 02期

关键词：

D O I：

10.1128/AAC.38.2.403

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 mu g ml(-1)), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight(-1)). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.

引用

页码：403 / 406

页数：4

共 26 条

[1] ABELES RH, 1990, J BIOL CHEM, V265, P16705
[2] BIOCHEMICAL BASIS FOR GLYCOPHOSPHATE-TOLERANCE IN A BACTERIUM AND A PLANT-TISSUE CULTURE
AMRHEIN, N
JOHANNING, D
SCHAB, J
SCHULZ, A
[J]. FEBS LETTERS, 1983, 157 (01) : 191 - 196
[3] [Anonymous], 1993, SHIKIMIC ACID METABO
[4] BACON GA, 1950, BRIT J EXP PATHOL, V31, P714
[5] INHIBITION OF CHORISMATE SYNTHASE BY (6R) AND (6S)-6-FLUORO-5-ENOLPYRUVYLSHIKIMATE 3-PHOSPHATE
BALASUBRAMANIAN, S
DAVIES, GM
COGGINS, JR
ABELL, C
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) : 8945 - 8946
[6] THE SHIKIMATE PATHWAY - A METABOLIC TREE WITH MANY BRANCHES
BENTLEY, R
[J]. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1990, 25 (05) : 307 - 384
[7] BORNEMANN S, IN PRESS 11TH P INTC
[8] Chatfield S., 1992, MOL BIOL BACTERIAL I, P299
[9] DAVIES GM, 1993, 33RD INT C ANT AG CH
[10] MUTANTS OF ESCHERICHIA-COLI REQUIRING METHIONINE OR VITAMIN-B12
DAVIS, BD
MINGIOLI, ES
[J]. JOURNAL OF BACTERIOLOGY, 1950, 60 (01) : 17 - 28

← 1 2 3 →