ANTERIOR-PITUITARY ADENYLATE-CYCLASE - STIMULATION BY DOPAMINE AND OTHER MONO-AMINES

被引：38

作者：

AHN, HS

GARDNER, E

MAKMAN, MH

机构：

[1] YESHIVA UNIV,ALBERT EINSTEIN COLL MED,DEPT MOLEC PHARMACOL,BRONX,NY 10461

[2] YESHIVA UNIV,ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,BRONX,NY 10461

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 53卷 / 03期

关键词：

Adenylate cyclase; Anterior pituitary; Apomorphine; Bromocriptine; Haloperidol; Lergotrile;

D O I：

10.1016/0014-2999(79)90139-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adenylate cyclase activity of homogenates of anterior pituitary from rat, rabbit and monkey was stimulated by dopamine, other amine neurotransmitters and Gpp(NH)p. The concentration of dopamine for half-maximal stimulation of activity was 2-5 μM. Studies with selective agonists and antagonists indicated the presence of dopamine receptors and β-adrenergic receptors coupled to adenylate cyclase in anterior pituitary. In addition, histamine stimulated activity in rabbit and monkey, but not in rat, anterior pituitary. © 1979.

引用

页码：313 / 317

页数：5

共 12 条

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