DATURA-STRAMONIUM AGGLUTININ-REACTIVE ALPHA-FETOPROTEIN ISOFORMS IN HEPATOCELLULAR-CARCINOMA AND OTHER TUMORS

被引：12

作者：

TAKETA, K

ICHIKAWA, E

YAMAMOTO, T

KATO, H

MATSUURA, S

TAGA, H

HIRAI, H

机构：

[1] WAKO PURE CHEM IND LTD,OSAKA RES DIV,OSAKA,JAPAN

[2] TUMOR LABS,KOKUBUNJI,JAPAN

来源：

TUMOR BIOLOGY | 1990年 / 11卷 / 04期

关键词：

Datura stramonium agglutinin; Hepatocellular carcinoma; Lectin affinity electrophoresis; α-Fetoprotein;

D O I：

10.1159/000217658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By means of Datura stramonium agglutinin (DSA) affinity electrophoresis, human a-fetoprotein (AFP) was resolved into five bands, AFP-D1, D2, D3, D4 and D5, in order of decreasing mobility. AFP-D1, which had no affinity for DSA, comprised more than 84% of the intensity of total AFP bands. The percentage of AFP-D2 increased marginally in hepatitis and liver cirrhosis with or without hepatocellular carcinoma. AFP-D3 increased characteristically in hepatocellular carcinoma and AFP-D4, which had the highest affinity for DSA, increased up to 12% in other tumors, mostly of gastrointestinal origin. AFP-D5 showed no consistent changes among the benign and malignant diseases. The assay of AFP- D3 and D4 proved useful as a highly specific marker of hapatocellular carcinoma and other tumors, respectively. © 1990 S. Karger AG, Basel.

引用

页码：220 / 228

页数：9

共 27 条

[1] FUCOSYLATION OF SERUM ALPHA-FETOPROTEIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR-CARCINOMA [J].