METABOLISM OF INTRAVENOUSLY ADMINISTERED CHOLECALCIFEROL IN MAN

被引：11

作者：

BARRAGRY, JM

FRANCE, MW

BOUCHER, BJ

COHEN, RD

机构：

[1] LONDON HOSP,COLL MED,METAB & ENDOCRINE UNIT,LONDON E1 1BB,ENGLAND

[2] LONDON HOSP,DEPT CLIN CHEM,LONDON E1 1BB,ENGLAND

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03101.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Following intravenous injection of (3H) cholecalciferol into healthy subjects the disappearance of label from the plasma was followed by the reappearance (‘rebound’) of (3H) radioactivity associated exclusively with cholecalciferol. Lipoprotein fractionation of plasma revealed an increasing association of label with protein rather than lipoprotein during the rebound phase. We conclude that the rebound of plasma radioactivity reflects the transfer of label from lipoprotein to Vitamin D‐binding globulin in the liver followed by its release into plasma. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：491 / 495

页数：5

共 11 条

[1] METABOLISM OF VITAMIN D3-3H IN HUMAN SUBJECTS - DISTRIBUTION IN BLOOD BILE FECES AND URINE [J].