PROTECTION BY TRIMIPRAMINE AGAINST GASTRIC-MUCOSAL BARRIER DYSFUNCTION INDUCED BY ETHANOL + HCL IN RATS

被引：4

作者：

DEREGNAUCOURT, J ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1979年 / 14卷 / 05期

关键词：

Gastric ulcer; Stomach; Trimipramine;

D O I：

10.3109/00365527909181393

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effects of trimipramine (5 mg · kg-1·h-1 intravenously) on the changes in gastric mucosal function evoked by 20% ethanol + HCl has been studied in rats. The magnitude of the changes in potential difference, ionic fluxes (H+, Na+, and K+), and mucosal lesion score induced by ethanol + HCl were significantly less in animals treated with trimipramine than in control animals. It is concluded that trimipramine decreases the gastric mucosal damage produced by ethanol + HCl in rats. This activity may be responsible, at least in part, for the beneficial effect of trimipramine treatment in peptic ulcer disease. © 1979 Informa UK Ltd.

引用

页码：583 / 585

页数：3