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COMPARATIVE EFFECTS OF EPIDERMAL GROWTH-FACTOR AND CARBACHOL ON PHOSPHOINOSITIDE SYNTHESIS AND BREAKDOWN IN PANCREATIC ACINAR-CELLS

被引：8
作者：
CONWAY, BR
LAYCHOCK, SG
RUBIN, RP
机构：
[1] SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT PHARMACOL & THERAPEUT,102 FARBER HALL,BUFFALO,NY 14214
[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,RICHMOND,VA 23298
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 02期
关键词：
D O I：
10.1016/0006-291X(91)90176-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Carbachol (CCh) and epidermal growth factor (EGF) elicited a concentration-dependent increase in [32P]phosphatidyl-inositol-4-phosphate (PtdIns-4P) formation in homogenates derived from agonist-stimulated rat pancreatic acini. The combination of CCh and EGF produced a response which was not synergistic or additive. EGF, unlike CCh, failed to cause [32P]PtdIns-4,5P2 breakdown, suggesting different mechanisms involved in the stimulation of [32P]PtdIns-4P formation induced by EGF and CCh. We conclude that PtdIns kinase represents a key component of the signaling pathways utilized by EGF and CCh in exocrine pancreas. © 1991.
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收藏
页码：780 / 785
页数：6
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