[H-3] HEMICHOLINIUM-3 BINDING IN RATS WITH STATUS EPILEPTICUS INDUCED BY LITHIUM-CHLORIDE AND PILOCARPINE

被引：6

作者：

YAMADA, K ^{[1
]}

SALTARELLI, MD ^{[1
]}

COYLE, JT ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT NEUROSCI PHARMACOL & PEDIAT,DIV CHILD PSYCHIAT,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 195卷 / 03期

关键词：

H-3]HEMICHOLINIUM-3; CHOLINE UPTAKE (HIGH-AFFINITY); ACETYLCHOLINE; PILOCARPINE; LITHIUM CHLORIDE; PHOSPHOLIPASE-A2;

D O I：

10.1016/0014-2999(91)90481-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The specific binding of [H-3]hemicholinium-3 ([H-3]HCh-3) and high-affinity [H-3]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine. The specific binding of [H-3]HCh-3 in cortex and hippocampus from rats with status epilepticus increased to 2- to 3-fold of control while the striatal [H-3]HCh-3 binding increased minimally. Scatchard analyses revealed that the observed changes resulted from an increase in B(max) of [H-3]HCh-3 binding. High-affinity [H-3]choline uptake remained unchanged. These results further implicate phospholipase A2 in the regulation of [H-3]HCh-3 binding sites.

引用

页码：395 / 397

页数：3

共 11 条

[1] CHARACTERIZATION OF LITHIUM POTENTIATION OF PILOCARPINE-INDUCED STATUS EPILEPTICUS IN RATS [J].