MELANOCYTE-STIMULATING PROPERTIES OF ARACHIDONIC-ACID METABOLITES - POSSIBLE ROLE IN POSTINFLAMMATORY PIGMENTATION

被引：180

作者：

TOMITA, Y ^{[1
]}

MAEDA, K ^{[1
]}

TAGAMI, H ^{[1
]}

机构：

[1] SHISEIDO LABS,YOKOHAMA,JAPAN

来源：

PIGMENT CELL RESEARCH | 1992年 / 5卷 / 05期

关键词：

LEUKOTRIENE; LTC(4); B-LOCUS PROTEIN; PROSTAGLANDIN; TYROSINASE; TYROSINASE-RELATED PROTEIN;

D O I：

10.1111/j.1600-0749.1992.tb00562.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of tyrosinase and immunoreactive b-locus protein when they were cultured for 2 days with the following arachidonic acid metabolites: prostaglandin (PG) D2, leukotriene (LT) B4, LTC4, LTD4, LTE4, thromboxane (TX) B2 and 12-hydroxy eicosatetraenoic acid (12-HETE). The effect of LTC4 was particularly strong compared to that of PGE2, about which we have previously reported. On the other hand, PGE1, PGF2alpha and 6-ketoPGF1alpha did not show any significant stimulatory effect. These data suggest that arachidonate-derived chemical mediators, especially LTC4, may be responsible for the induction of post-inflammatory hyperpigmentation of the skin.

引用

页码：357 / 361

页数：5

共 33 条

[1] EFFLUX OF PROSTAGLANDINS IN LYMPH FROM SCALDED TISSUE [J].