MELANOCYTE-STIMULATING PROPERTIES OF ARACHIDONIC-ACID METABOLITES - POSSIBLE ROLE IN POSTINFLAMMATORY PIGMENTATION

被引:180
作者
TOMITA, Y [1 ]
MAEDA, K [1 ]
TAGAMI, H [1 ]
机构
[1] SHISEIDO LABS,YOKOHAMA,JAPAN
来源
PIGMENT CELL RESEARCH | 1992年 / 5卷 / 05期
关键词
LEUKOTRIENE; LTC(4); B-LOCUS PROTEIN; PROSTAGLANDIN; TYROSINASE; TYROSINASE-RELATED PROTEIN;
D O I
10.1111/j.1600-0749.1992.tb00562.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of tyrosinase and immunoreactive b-locus protein when they were cultured for 2 days with the following arachidonic acid metabolites: prostaglandin (PG) D2, leukotriene (LT) B4, LTC4, LTD4, LTE4, thromboxane (TX) B2 and 12-hydroxy eicosatetraenoic acid (12-HETE). The effect of LTC4 was particularly strong compared to that of PGE2, about which we have previously reported. On the other hand, PGE1, PGF2alpha and 6-ketoPGF1alpha did not show any significant stimulatory effect. These data suggest that arachidonate-derived chemical mediators, especially LTC4, may be responsible for the induction of post-inflammatory hyperpigmentation of the skin.
引用
收藏
页码:357 / 361
页数:5
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