DIFFUSION OF PEPTIDES THROUGH HYDROGEL MEMBRANES

被引：32

作者：

DOMB, A ^{[1
]}

DAVIDSON, GWR ^{[1
]}

SANDERS, LM ^{[1
]}

机构：

[1] SYNTEX RES,3401 HILLVIEW AVE,PALO ALTO,CA 94303

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 14卷 / 02期

关键词：

hydration; hydrogel membranes; luteinizing hormone releasing hormone; nafaralin; poly(hydroxyalkyl methacrylate);

D O I：

10.1016/0168-3659(90)90150-R

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory. © 1990.

引用

页码：133 / 144

页数：12

共 12 条

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