ROLE OF FATTY-ACIDS IN SIGNAL TRANSDUCTION - MODULATORS AND MESSENGERS

被引:132
作者
SUMIDA, C
GRABER, R
NUNEZ, E
机构
[1] INSERM U224, Faculté de Médecine Xavier Bichat, 75018 Paris
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 48卷 / 01期
关键词
D O I
10.1016/0952-3278(93)90019-S
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many of the steps involved in signal transduction are regulated positively or negatively by fatty acids (FA) per se. FA have been shown to act both as modulators and messengers, particularly of signals triggered at the level of cell membranes. Enzymes and proteins of the cyclic AMP and the protein kinase C signalling pathways and those involving ion fluxes and mobilization are both activated and/or inhibited by FA. FA can also participate in a feedback control mechanism since phospholipases are themselves modulated by FA. FA, particularly arachidonic acid liberated from membrane phospholipids, are also second messengers in signal transduction, and a good example is the activation of protein kinase C by FA. FA play an important role in regulating the transmission of signals from the extracellular environment by acting as modulators and messengers within the complex intracellular network of relays.
引用
收藏
页码:117 / 122
页数:6
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