WILMS-TUMOR IN A PATIENT WITH PRADER-WILLI SYNDROME

被引：10

作者：

COPPES, MJ

SOHL, H

TESHIMA, IE

MUTIRANGURA, A

LEDBETTER, DH

WEKSBERG, R

机构：

[1] CLEVELAND CLIN EDUC FDN, RES INST, DEPT CANC BIOL, CLEVELAND, OH 44106 USA

[2] HOSP SICK CHILDREN, DEPT PEDIAT, DIV HEMATOL ONCOL, TORONTO M5G 1X8, ONTARIO, CANADA

[3] HOSP SICK CHILDREN, DEPT GENET, DIV HEMATOL ONCOL, TORONTO M5G 1X8, ONTARIO, CANADA

[4] BAYLOR COLL MED, INST MOLEC GENET, HOUSTON, TX 77030 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 122卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(06)80015-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The development of Wilms tumor in a patient with Prader-Willi syndrome prompted us to determine the parental origin of the genes implicated in both disorders because of the sex-specific parent-of-origin effects previously demonstrated for both conditions. A paternal chromosome 15q11-q13 deletion was demonstrated, but no changes were demonstrated in a limited analysis of chromosome 11p, which harbors two Wilms tumor suppressor genes, WT1 and WT2.

引用

页码：730 / 733

页数：4

共 15 条

[1]

Cassidy S B, 1984, Curr Probl Pediatr, V14, P1

[2] HOMOZYGOUS SOMATIC WT1 POINT MUTATIONS IN SPORADIC UNILATERAL WILMS-TUMOR [J].