DETERMINATION OF (R) AND (S) WARFARIN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING PRECOLUMN DERIVATIZATION

被引：6

作者：

AYCARD, M ^{[1
]}

LETELLIER, S ^{[1
]}

MAUPAS, B ^{[1
]}

GUYON, F ^{[1
]}

机构：

[1] LAB CHIM ANALYT,UFR SCI PHARMACEUT & BIOL,F-75270 PARIS 06,FRANCE

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1992年 / 15卷 / 12期

关键词：

D O I：

10.1080/10826079208016333

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomers of warfarin were determined in human plasma after derivatization of warfarin with (-)1-menthylchloroformate to form diastereomeric derivatives and separation by HPLC on a silica column. The analytical method was employed to determine human plasma level of warfarin enantiomers after administration of racemate .

引用

页码：2175 / 2182

页数：8

共 7 条

[1] OPTICAL RESOLUTION BY LIQUID-CHROMATOGRAPHY ON IMMOBILIZED BOVINE SERUM-ALBUMIN
ALLENMARK, S
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3): : 425 - 442
[2] IMPLICATIONS OF THE NEGLECT OF STEREOCHEMISTRY IN PHARMACOKINETICS AND CLINICAL-PHARMACOLOGY
ARIENS, EJ
[J]. DRUG INTELLIGENCE & CLINICAL PHARMACY, 1987, 21 (10): : 827 - 829
[3] COOK CE, 1979, J PHARMACOL EXP THER, V210, P391
[4] HOGLUNG P, 1989, THER DRUG MONIT, V1, P667
[5] NEW METHOD FOR THE RESOLUTION OF RACEMIC WARFARIN AND ITS ANALOGS USING LOW-PRESSURE LIQUID-CHROMATOGRAPHY
JEYARAJ, GL
PORTER, WR
[J]. JOURNAL OF CHROMATOGRAPHY, 1984, 315 (DEC): : 378 - 383
[6] MAUPAS B, 1989, ANALUSIS, V17, P468
[7] ENOXACIN-WARFARIN INTERACTION - PHARMACOKINETIC AND STEREOCHEMICAL ASPECTS
TOON, S
HOPKINS, KJ
GARSTANG, FM
AARONS, L
SEDMAN, A
ROWLAND, M
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 42 (01) : 33 - 41

← 1 →