DISAPPEARANCE OF THE LYMPHOID SYSTEM IN BCL-2 HOMOZYGOUS MUTANT CHIMERIC MICE

被引：384

作者：

NAKAYAMA, K

NEGISHI, I

KUIDA, K

SHINKAI, Y

LOUIE, MC

FIELDS, LE

LUCAS, PJ

STEWART, V

ALT, FW

LOH, DY

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT MED, HOWARD HUGHES MED INST, ST LOUIS, MO 63110 USA

[2] WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

[3] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA

[4] HARVARD UNIV, CHILDRENS HOSP,SCH MED,DEPT GENET, HOWARD HUGHES MED INST, BOSTON, MA 02115 USA

[5] CTR BLOOD RES, BOSTON, MA 02115 USA

来源：

SCIENCE | 1993年 / 261卷 / 5128期

关键词：

D O I：

10.1126/science.8372353

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes without Bcl-2 differentiated into phenotypically mature cells. However, in vitro, the mature T cells that lacked Bcl-2 had shorter life-spans and increased sensitivity to glucocorticoids and gamma-irradiation. In contrast, stimulation of CD3 inhibited the death of these cells. T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth.

引用

页码：1584 / 1588

页数：5

共 36 条

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