THROMBOCYTOPENIA FOLLOWING ADMINISTRATION OF PHENYTOIN, DEXAMETHASONE AND CIMETIDINE - A CASE-REPORT AND A POTENTIAL MECHANISM

被引:8
作者
ARBISER, JL
GOLDSTEIN, AM
GORDON, D
机构
[1] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215
[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115
关键词
CIMETIDINE; DEXAMETHASONE; EPOXIDE HYDROLASE; PHENYTOIN; THROMBOCYTOPENIA;
D O I
10.1111/j.1365-2796.1993.tb00710.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cimetidine and phenytoin are useful medications often used together in patients with seizure disorders secondary to brain masses or metabolic abnormalities. We describe a case of thrombocytopenia in the setting of concurrent phenytoin, dexamethasone and cimetidine administration, and compare it with previously described cases of thrombocytopenia induced by concurrent use of phenytoin, cimetidine, and glucocorticoids. The similarities between these cases suggest mechanisms by which these agents may induce thrombocytopenia, specifically through potential downregulation of epoxide hydrolase by glucocorticoids.
引用
收藏
页码:91 / 94
页数:4
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