LYMPHOCYTE-RESPONSE IN-VITRO TO PLASMODIUM-FALCIPARUM MEROZOITE ANTIGENS IN DONORS FROM A HOLOENDEMIC AREA

被引:12
作者
DIEYE, A
HEIDRICH, HG
ROGIER, C
TRAPE, JF
LAUNOIS, P
HOLDER, AA
SARTHOU, JL
机构
[1] INST PASTEUR, IMMUNOL UNIT, DAKAR, SENEGAMBIA
[2] MAX PLANCK INST BIOCHEM, D-80794 MUNICH, GERMANY
[3] INST DAKAR, SERV EPIDEMIOL, DAKAR, SENEGAMBIA
[4] ORSTOM, DAKAR, SENEGAMBIA
[5] NATL INST MED RES, LONDON, ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1007/BF00932503
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Crude merozoite antigens from Plasmodium falciparum were used to evaluate the proliferative response of peripheral mononuclear cells (PBMCs) from 114 inhabitants of the village of Dielmo (Senegal, West Africa) exposed continuously to malaria transmission. The high or low responses to merozoite antigens obtained in lymphocyte stimulation assays were correlated with the presence or absence of parasites, IFN-gamma production and HLA phenotype. The high responders produced high levels of IFN-gamma, in contrast to the low responders, most of whom did not secrete IFN-gamma (23/27). Among others, the two HLA phenotypes HLA-B51 and HLA-DR1 were significantly associated with a high response (P<0.05).
引用
收藏
页码:629 / 633
页数:5
相关论文
共 32 条
[1]  
BEHR C, 1992, J IMMUNOL, V149, P3321
[2]   HLA AND TROPICAL SPLENOMEGALY SYNDROME IN THE UPPER WATUT VALLEY OF PAPUA-NEW-GUINEA [J].
BHATIA, K ;
CRANE, G .
HUMAN IMMUNOLOGY, 1985, 13 (04) :235-242
[3]   NOMENCLATURE FOR FACTORS OF THE HLA SYSTEM, 1990 [J].
BODMER, JG ;
MARSH, SGE ;
ALBERT, ED ;
BODMER, WF ;
DUPONT, B ;
ERLICH, HA ;
MACH, B ;
MAYR, WR ;
PARHAM, P ;
SASAZUKI, T ;
SCHREUDER, GMT ;
STROMINGER, JL ;
SVEJGAARD, A ;
TERASAKI, PI .
TISSUE ANTIGENS, 1991, 37 (03) :97-104
[4]   IMMUNE-RESPONSES TO THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM IN RELATION TO HLA-DR TYPE [J].
BROWN, AE ;
CHANDANAYINGYONG, D ;
FUGGLE, SV ;
WEBSTER, HK .
TISSUE ANTIGENS, 1989, 34 (03) :200-204
[5]   RESTRICTED OR ABSENT IMMUNE-RESPONSES IN HUMAN-POPULATIONS TO PLASMODIUM-FALCIPARUM GAMETE ANTIGENS THAT ARE TARGETS OF MALARIA TRANSMISSION-BLOCKING ANTIBODIES [J].
CARTER, R ;
GRAVES, PM ;
QUAKYI, IA ;
GOOD, MF .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :135-147
[6]   LYMPHOPROLIFERATIVE RESPONSES TO SYNTHETIC PEPTIDES FROM MEROZOITE RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN AND CIRCUMSPOROZOITE PROTEIN - A LONGITUDINAL-STUDY DURING A FALCIPARUM-MALARIA EPISODE [J].
CHOUGNET, C ;
LEPERS, JP ;
ASTAGNEAU, P ;
RASON, MD ;
SAVEL, J ;
DELORON, P .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 45 (05) :560-566
[7]  
DEGROOT AS, 1989, J IMMUNOL, V142, P4000
[8]  
Dieye A, 1991, Dakar Med, V36, P185
[9]   PLASMODIUM-FALCIPARUM MEROZOITES PRIMARILY STIMULATE THE V-GAMMA-9 SUBSET OF HUMAN GAMMA/DELTA-T-CELLS [J].
GOERLICH, R ;
HACKER, G ;
PFEFFER, K ;
HEEG, K ;
WAGNER, H .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (10) :2613-2616
[10]  
Goerlich R., 1992, Journal of Protozoology Research, V2, P53