PARALLEL NUCLEIC-ACID HELICES WITH HOOGSTEEN BASE-PAIRING - SYMMETRY AND STRUCTURE

被引：31

作者：

RAGHUNATHAN, G ^{[1
]}

MILES, HT ^{[1
]}

SASISEKHARAN, V ^{[1
]}

机构：

[1] NIDDKD,MOLEC BIOL LAB,BETHESDA,MD 20892

来源：

BIOPOLYMERS | 1994年 / 34卷 / 12期

关键词：

D O I：

10.1002/bip.360341202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular structures for parallel DNA and RNA double helices with Hoogsteen pairing are proposed for the first time. The DNA helices have sugars in the C2'-endo region and the phosphodiester conformations are (trans, gauche(-)), and the RNA helices have sugars in the C3'-endo region and the phosphodiester conformations are (gauche(-), gauche(-)). A pseudorotational symmetry relates the two parallel strands of DNA helices and a screw symmetry relates the two strands of RNA helices, which have an associated tilt of the bases. The conformational space of parallel helices with Hoogsteen base pairing, unlike the Watson-Crick duplex, is highly restricted due to the unique positioning of the symmetry axis in the former case. The features of the parallel double helix with Hoogsteen pairing are compared with the Watson-Crick duplex and the corresponding triple helix. (C) 1994 John Wiley & Sons, Inc.

引用

收藏

页码：1573 / 1581

页数：9

相关论文

共 33 条

[1] STRUCTURES FOR POLY(U).POLY(A).POLY(U) TRIPLE STRANDED POLYNUCLEOTIDES [J].

ARNOTT, S ;

BOND, PJ .

NATURE-NEW BIOLOGY, 1973, 244 (134) :99-101

[2] STRUCTURES FOR POLYNUCLEOTIDE COMPLEXES POLY(DA).POLY(DT) AND POLY(DT).POLY(DA).POLY(DT) [J].

ARNOTT, S ;

SELSING, E .

JOURNAL OF MOLECULAR BIOLOGY, 1974, 88 (02) :509-+

[3] FORMATION OF DNA TRIPLEXES ACCOUNTS FOR ARRESTS OF DNA-SYNTHESIS AT D(TC)N AND D(GA)N TRACTS [J].

BARAN, N ;

LAPIDOT, A ;

MANOR, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (02) :507-511

[4] INHIBITION OF SIMIAN VIRUS-40 DNA-REPLICATION IN CV-1 CELLS BY AN OLIGODEOXYNUCLEOTIDE COVALENTLY LINKED TO AN INTERCALATING AGENT [J].

BIRG, F ;

PRASEUTH, D ;

ZERIAL, A ;

THUONG, NT ;

ASSELINE, U ;

LEDOAN, T ;

HELENE, C .

NUCLEIC ACIDS RESEARCH, 1990, 18 (10) :2901-2908

[5] CRYSTAL STRUCTURES OF SALTS OF METHYLATED PURINES AND PYRIMIDINES .1. 1-METHYLCYTOSINE HYDROBROMIDE [J].

BRYAN, RF ;

TOMITA, KI .

ACTA CRYSTALLOGRAPHICA, 1962, 15 (NOV) :1174-&

[6] SITE-SPECIFIC OLIGONUCLEOTIDE BINDING REPRESSES TRANSCRIPTION OF THE HUMAN C-MYC GENE INVITRO [J].

COONEY, M ;

CZERNUSZEWICZ, G ;

POSTEL, EH ;

FLINT, SJ ;

HOGAN, ME .

SCIENCE, 1988, 241 (4864) :456-459

[7]

Coxeter H. S. M., 1963, REGULAR POLYTOPES

[8]

CRISTOPHE D, 1985, NUCLEIC ACIDS RES, V13, P5127

[9] MOLECULAR-STRUCTURE OF A DOUBLE HELIX THAT HAS NON-WATSON-CRICK TYPE BASE-PAIRING FORMED BY 2-SUBSTITUTED POLY(A) AND POLY(U) [J].

HAKOSHIMA, T ;

FUKUI, T ;

IKEHARA, M ;

TOMITA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7309-7313

[10] INTRAMOLECULAR DNA TRIPLEXES IN SUPERCOILED PLASMIDS [J].

HANVEY, JC ;

SHIMIZU, M ;

WELLS, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (17) :6292-6296

← 1 2 3 4 →