ACYCLOVIR-INDUCED NEUTROPENIA IN AN INFANT WITH HERPES-SIMPLEX ENCEPHALITIS - CASE-REPORT

被引：16

作者：

FEDER, HM

GOYAL, RK

KRAUSE, PJ

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,FARMINGTON,CT 06030

[2] HARTFORD HOSP,DEPT PEDIAT,HARTFORD,CT 06115

来源：

CLINICAL INFECTIOUS DISEASES | 1995年 / 20卷 / 06期

关键词：

D O I：

10.1093/clinids/20.6.1557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A newborn infant whose condition was diagnosed as herpes simplex encephalitis and who had subsequent recurrences of skin disease had repeated episodes of neutropenia while receiving therapy with intravenous (30 mg/[kg . d]) or oral (30 mg/[kg . d]) acyclovir. The neutropenia did not recur when the dosage of oral acyclovir was reduced to 10 mg/(kg . d). This case represents the first well-documented report of acyclovir-induced neutropenia.

引用

页码：1557 / 1559

页数：3

共 22 条

[1]

BEAN B, 1985, 25 INT C ANT AG CHEM, P237

[2]

BUHLES WC, 1988, REV INFECT DIS, V10, pS495

[3] DRUGS 5 YEARS LATER - ACYCLOVIR [J].

DORSKY, DI ;

CRUMPACKER, CS .

ANNALS OF INTERNAL MEDICINE, 1987, 107 (06) :859-874

[4] A DOUBLE-BLIND-STUDY OF ORAL ACYCLOVIR FOR SUPPRESSION OF RECURRENCES OF GENITAL HERPES-SIMPLEX VIRUS-INFECTION [J].

DOUGLAS, JM ;

CRITCHLOW, C ;

BENEDETTI, J ;

MERTZ, GJ ;

CONNOR, JD ;

HINTZ, MA ;

FAHNLANDER, A ;

REMINGTON, M ;

WINTER, C ;

COREY, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (24) :1551-1556

[5] A CONTROLLED TRIAL OF ACYCLOVIR FOR CHICKENPOX IN NORMAL-CHILDREN [J].

DUNKLE, LM ;

ARVIN, AM ;

WHITLEY, RJ ;

ROTBART, HA ;

FEDER, HM ;

FELDMAN, S ;

GERSHON, AA ;

LEVY, ML ;

HAYDEN, GF ;

MCGUIRT, PV ;

HARRIS, J ;

BALFOUR, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (22) :1539-1544

[6]

ECK P, 1991, NEW ENGL J MED, V325, P1178

[7] ACYCLOVIR THERAPY IN NEONATES [J].

ENGLUND, JA ;

FLETCHER, CV ;

BALFOUR, HH .

JOURNAL OF PEDIATRICS, 1991, 119 (01) :129-135

[8] PROLONGED CONTINUOUS ACYCLOVIR TREATMENT OF NORMAL ADULTS WITH FREQUENTLY RECURRING GENITAL HERPES-SIMPLEX VIRUS-INFECTION [J].

KAPLOWITZ, LG ;

BAKER, D ;

GELB, L ;

BLYTHE, J ;

HALE, R ;

FROST, P ;

CRUMPACKER, C ;

RABINOVICH, S ;

PEACOCK, JE ;

HERNDON, J ;

DAVIS, LG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (06) :747-751

[9]

KENNEY RE, 1982, AM J MED S6A, V73, P176

[10] LACK OF TOXICITY IN 2 CASES OF NEONATAL ACYCLOVIR OVERDOSE [J].

MCDONALD, LK ;

TARTAGLIONE, TA ;

MENDELMAN, PM ;

OPHEIM, KE ;

COREY, L .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1989, 8 (08) :529-532

← 1 2 3 →