EFFECT OF GLYCOLIPIDS DETECTABLE IN TRANSFORMED HUMAN CELLS ON INTERFERON ACTIVITIES

被引：26

作者：

KUWATA, T ^{[1
]}

HANDA, S ^{[1
]}

FUSE, A ^{[1
]}

MORINAGA, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT BIOCHEM,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 85卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(78)80013-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human transformed cell lines, RSa, RSb, and IFr, were analyzed for their glycolipid composition. Ganglioside GM2, GM3, and 4 neutral glycolipids were identified as the component of these 3 cell lines. Antiviral action of human interferon was neutralized by pretreatment with GM3 or GM2. Lactosylceramide also neutralized antiviral action of human interferon. Thus, these glycolipids are considered to be the components of the receptor for interferon in these cells. However, when GM3 or ganglioside mixture was tested for the anticellular action of human interferon, they showed no inhibitory action on the growth suppressive activity of interferon. © 1978 Academic Press, Inc.

引用

页码：77 / 84

页数：8

共 27 条

[1]

ANDO S, 1973, J BIOCHEM-TOKYO, V73, P387

[2] BINDING OF INTERFERON TO GANGLIOSIDES [J].