EVIDENCE FOR LYSOSOMAL REDUCTION OF CYSTINE RESIDUES

被引：19

作者：

GRIFFITHS, PA

LLOYD, JB

机构：

[1] Biochemistry Research Laboratory, Department of Biological Sciences, University of Keele, Keele

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)90647-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously reported evidence for the existence of a thiol: protein disulphide oxidoreductase in rat liver lysosomes has been re-examined and ambiguous results obtained. However, incubation of purified rat liver lysosomes with 125I-labelled insulin at pH 5.5 shows that cathepsin D and a thiol-dependent enzyme other than cathepsin B or L are important in its digestion. The latter enzyme is most probably a thiol: protein disulphide oxidoreductase. © 1979.

引用

页码：428 / 434

页数：7

共 17 条

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