PHARMACOKINETICS OF CEPHRADINE SUSPENSION IN INFANTS AND CHILDREN

被引:8
作者
GINSBURG, CM
MCCRACKEN, GH
机构
关键词
D O I
10.1128/AAC.16.1.74
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The pharmacokinetics of cephradine suspension were studied in 16 infants and children who were 13 months to 8 years and 3 months of age (mean age, 3.5 years). Mean peak concentrations of 21.3 and 9.9 μg/ml were achieved at 30 min after administration of 60-mg/kg doses to fasting and nonfasting patients. The area under the serum concentration-time curve was 26% larger in fasting than in fed subjects. The half-life of cephradine in serum was 0.8 and 1.0 h in fasting and fed groups, respectively. Antimicrobial activity was detected in 49% of all salivary samples; in 75% of specimens, the concentrations were less than the 50% minimum inhibitory concentration for most pneumococci and group A streptococci. Urinary concentrations of cephradine ranged from 28 to 8,760 μg/ml and were independent of feeding status.
引用
收藏
页码:74 / 76
页数:3
相关论文
共 8 条
[1]  
GRADESBUSCH HH, 1972, ADV ANTIMICROB ANTIN, V1, P1059
[2]   CEPHRADINE ABSORPTION AND EXCRETION IN FASTING AND NONFASTING VOLUNTEERS [J].
HARVENGT, C ;
DESCHEPP.P ;
LAMY, F ;
HANSEN, J .
JOURNAL OF CLINICAL PHARMACOLOGY, 1973, 13 (01) :36-40
[3]  
MCCRACKEN GH, 1978, PEDIATRICS, V62, P738
[4]   INFLUENCE OF PROBENECID AND FOOD ON BIOAVAILABILITY OF CEPHRADINE IN NORMAL MALE SUBJECTS [J].
MISCHLER, TW ;
SUGERMAN, AA ;
WILLARD, DA ;
BRANNICK, LJ ;
NEISS, ES .
JOURNAL OF CLINICAL PHARMACOLOGY, 1974, 14 (11-1) :604-611
[5]  
RITSCHEL WA, 1976, HDB BASIC PHARMACOKI, P235
[6]   MICROBIOASSAY OF ANTIMICROBIAL AGENTS [J].
SIMON, HJ ;
YIN, EJ .
APPLIED MICROBIOLOGY, 1970, 19 (04) :573-&
[7]   CLINICAL PHARMACOLOGY OF ORAL CEPHRADINE [J].
ZAKI, A ;
SCHREIBER, EC ;
WELIKY, I ;
KNILL, JR ;
HUBSHER, JA .
JOURNAL OF CLINICAL PHARMACOLOGY, 1974, 14 (2-3) :118-126
[8]  
ZAR G, 1974, BIOSTATISTICAL STATI