PREPARATION AND ANTIVIRAL ACTIVITY OF SEVERAL DEOXYGENATED RIBAVIRIN AND TIAZOFURIN DERIVATIVES

被引：11

作者：

UPADHYA, K

DARE, J

SCHUBERT, EM

机构：

[1] PHARM ECO LABS,2355 CHAIN DR,SIMI VALLEY,CA 93065

[2] NCI,FREDERICK CANC RES FACIL,PROGRAM RESOURCES INC,FREDERICK,MD 21701

[3] USA,MED RES INST INFECT DIS,FREDERICK,MD 21701

来源：

NUCLEOSIDES & NUCLEOTIDES | 1990年 / 9卷 / 05期

关键词：

D O I：

10.1080/07328319008045196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribavirin and tiazofurin, two nucleosides of known antiviral activity, have been transformed by previously reported methods to yield several deoxy,epoxy, or dideoxy analogues. The deoxygenated derivatives were evaluated for antiviral activity against a host of DNA and RNA viruses; however, no significant in vitro activity was detected. © 1990, Taylor & Francis Group, LLC. All rights reserved.

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页码：649 / 662

页数：14

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