ENHANCEMENT OF CLOT FORMATION OF HUMAN PLASMA BY BETA-GLUCANS

被引:27
作者
OHNO, N [1 ]
SUZUKI, T [1 ]
SAITO, K [1 ]
YADOMAE, T [1 ]
机构
[1] TOKYO METROPOLITAN RES LAB PUBL HLTH, SHINJUKU KU, TOKYO 169, JAPAN
来源
JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 09期
关键词
(1→3)-β-D-glucan; factor XII; fibrinogen; grifolan; human plasma clotting; steric exclusion;
D O I
10.1248/bpb1978.13.525
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Effects of (1→3)-β-D-glucans on clot formation of human plasma were examined. Gel forming 6 branched (1→3)-β-D-glucans, SSG, branched at every other main chain glucosyl unit, grifolan (GRN) and schizophyllan, branched at one third of main chain glucosyl unit, enhanced clot formation of human plasma. GRN derivatives also increased the contents of clot, but less effectively than GRN. This effect was dependent on dose, molecular weight (>20K), side chain (branching), and ultrastructure (single chain conformer) of the β-glucans. It may be important for the mechanism of (1→3)-β-D-glucan induced enhancement of plasma clotting to activate factor XII, to bind with fibrinogen, and to increase the local concentration of the clotting system by steric exclusion. © 1990, The Pharmaceutical Society of Japan. All rights reserved.
引用
收藏
页码:525 / 532
页数:8
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