INTERSTITIAL DRUG-THERAPY FOR BRAIN-TUMORS - A CASE-STUDY

被引:23
作者
CHASIN, M
HOLLENBECK, G
BREM, H
GROSSMAN, S
COLVIN, M
LANGER, R
机构
[1] UNIV MARYLAND,SCH PHARM,IND PHARM LAB,COLLEGE PK,MD 20742
[2] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205
[3] MIT,CAMBRIDGE,MA 02139
关键词
D O I
10.3109/03639049009058548
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A novel method of delivering cancer chemotherapeutic drugs to the brain in concentrations higher than those achievable by standard routes of administration has been developed. The drug was incorporated into wafers (trademarked BIODEL(R)) of a biodegradable, biocompatible polymer. The drug chosen for initial studies was BCNU (carmustine, 1,3-bis[2-chloroethyl]-1-nitrosourea), the most widely used chemotherapeutic agent for the disease to be treated, glioblastoma multiforme, a universally fatal form of brain cancer. Preclinical studies in a number of species demonstrated the safety of this material implanted either directly into the brain or subcutaneously. Efficacy studies in rats demonstrated that implanting BIODEL(R) wafers containing BCNU either at the time of tumor implantation or after 4 days of tumor growth could significantly prolong survival of the animals, while greatly diminishing side effects of the BCNU therapy. The safety of this material implanted into these patients during a Phase I/II study has been demonstrated. No systemic side effects of doses of BCNU which would produce marked effects on the hemopoeitic system when injected intravenously have been observed. Further studies, designed to measure the efficacy of this approach to the treatment of brain cancer in a multicentered Phase III clinical trial in the United States and Canada, are currently underway.
引用
收藏
页码:2579 / 2594
页数:16
相关论文
共 16 条
  • [1] Alberts D S, 1980, Prog Clin Biol Res, V48, P197
  • [2] ALBERTS DS, 1976, CANCER RES, V36, P2785
  • [3] BIOCOMPATIBILITY OF A BIODEGRADABLE, CONTROLLED-RELEASE POLYMER IN THE RABBIT BRAIN
    BREM, H
    KADER, A
    EPSTEIN, JI
    TAMARGO, RJ
    DOMB, A
    LANGER, R
    LEONG, KW
    [J]. SELECTIVE CANCER THERAPEUTICS, 1989, 5 (02): : 55 - 65
  • [4] BREM H, 1988, 1988 ANN M AM ASS NE, P349
  • [5] BREM H, IN PRESS J NEUROSURG
  • [6] CHASIN M, 1988, BIOPHARM MANUF, V1, P33
  • [7] POLYANHYDRIDES .1. PREPARATION OF HIGH-MOLECULAR-WEIGHT POLYANHYDRIDES
    DOMB, AJ
    LANGER, R
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1987, 25 (12) : 3373 - 3386
  • [8] GROSSMAN SA, UNPUB INTRACEREBRAL
  • [9] LAURENCIN C, IN PRESS J BIOMED MA
  • [10] LAURENCIN CT, 1987, P INT S CONTROL REL, V14, P140