ELECTROSPRAY IONIZATION MASS-SPECTROMETRY OF PLATINUM ANTICANCER AGENTS

被引：33

作者：

POON, GK ^{[1
]}

MISTRY, P ^{[1
]}

LEWIS, S ^{[1
]}

机构：

[1] FINNIGAN MAT CORP,SAN JOSE,CA 95134

来源：

BIOLOGICAL MASS SPECTROMETRY | 1991年 / 20卷 / 11期

关键词：

D O I：

10.1002/bms.1200201106

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Quantification and identification of platinum drugs and their metabolites in biological samples has always been difficult because these compounds are thermally unstable, non-volatile and insoluble. We have demonstrated that electrospray ionization mass spectrometry can be a valuable technique for direct mass spectral analysis of platinum anticancer agents and for obtaining structural information as a result of fragmentation. Full-scan spectra were obtained with approximately 10 pmol samples. These results show the potential of applying this technique in pharmacokinetic studies of platinum anticancer drugs.

引用

页码：687 / 692

页数：6

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