COMPARATIVE-EVALUATION OF IMMUNIZATION WITH LIVE ATTENUATED AND ENHANCED-POTENCY INACTIVATED TRIVALENT POLIOVIRUS VACCINES IN CHILDHOOD - SYSTEMIC AND LOCAL IMMUNE-RESPONSES

被引：156

作者：

FADEN, H

MODLIN, JF

THOMS, ML

MCBEAN, AM

FERDON, MB

OGRA, PL

机构：

[1] SUNY BUFFALO, SCH MED, DEPT PEDIAT, DIV INFECT DIS, BUFFALO, NY 14214 USA

[2] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT INT HLTH, BALTIMORE, MD 21218 USA

[3] JOHNS HOPKINS UNIV, SCH MED, DEPT PEDIAT, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 162卷 / 06期

关键词：

D O I：

10.1093/infdis/162.6.1291

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum neutralizing, nasopharyngeal neutralizing, and 1gA antibodies were determined in 123 infants immunized with one of four schedules containing live oral vaccine (OPV), inactivated vaccine (IPV), or combinations of the two trivalent poliovirus vaccines: OPV-OPV-OPV, IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV. Nearly 100% of individuals formed serum neutralizing antibodies. The highest geometric mean titer (GMT) of antibody to polioviruses 1, 2, and 3 occurred in groups IPV-IPV-OPV, IPV-OPV-OPV, and IPV-IPV-IPV, respectively. Local neutralizing and 1gA antibody responses were detected in 41%–88% and 75%–100%, respectively. Peak GMT of nasopharyngeal antibodies differed minimally between immunization groups. The data suggest that incorporation of at least one dose of IPV at the start of the immunization schedule tends to increase systemic as well as local antibody production. © 1990, by The University of Chicago.

引用

页码：1291 / 1297

页数：7

共 30 条

[1]

ALBRECHT P, 1984, REV INFECT DIS, V6, pS540

[2]

BATSON R, 1958, PEDIATRICS, V21, P1

[3]

BODIAN D, 1960, B JOHNS HOPKINS HOSP, V107, P143

[4]

BROWN GC, 1961, POLIOMYELITIS, P146

[5]

Fleiss JL., 1981, STAT METHODS RATES P, V2

[6]

GHENDON YZ, 1961, ACTA VIROL, V5, P265

[7] QUANTITATIVE RELATIONSHIP OF PREEXISTING HOMOTYPIC ANTIBODIES TO EXCRETION OF ATTENUATED POLIOVIRUS TYPE 1 [J].

GLEZEN, WP ;

LAMB, GA ;

BELDEN, EA ;

CHIN, TDY .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1966, 83 (02) :224-&

[8]

GRENIER B, 1984, REV INFECT DIS, V6, pS545

[9] A STUDY OF POLIOVACCINATION IN INFANCY - EXCRETION FOLLOWING CHALLENGE WITH LIVE VIRUS BY CHILDREN GIVEN KILLED OR LIVING POLIOVACCINE [J].

HENRY, JL ;

JAIKARAN, ES ;

DAVIES, JR ;

TOMLINSON, AJ ;

MASON, PJ ;

BARNES, JM ;

BEALE, AJ .

JOURNAL OF HYGIENE-CAMBRIDGE, 1966, 64 (01) :105-+

[10]

HOVI T, 1986, LANCET, V1, P1427

← 1 2 3 →