OLIGOTYPING OF ITALIAN CELIAC PATIENTS WITH THE 11TH INTERNATIONAL HISTOCOMPATIBILITY WORKSHOP REAGENTS

被引：8

作者：

FERRANTE, P

PETRONZELLI, F

MARIANI, P

BONAMICO, M

MAZZILLI, MC

机构：

[1] UNIV ROME LA SAPIENZA,DEPT EXPTL MED,I-00185 ROME,ITALY

[2] UNIV ROME LA SAPIENZA,DEPT PEDIAT,I-00185 ROME,ITALY

来源：

TISSUE ANTIGENS | 1992年 / 39卷 / 01期

关键词：

CD; HLA CLASS-II;

D O I：

10.1111/j.1399-0039.1992.tb02155.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oligotyping for HLA-DRB1, DQA1 and DQB1 specificities has been performed on PCR-amplified DNA from 55 Italian celiac children, living in Rome, and 50 blood donors. 52.6% of CD patients were DR3;DQA1*0501; DQB1*0201 - positive versus 14% of controls (RR = 6.85) and 34.5% were DR5,7; DQA1*0501; DQB1*0201 - positive versus of controls (RR = 25.86). 7 patients (12.7%) were negative for the DQA1*0501/B1*0201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7; 5,7 and w6.7. No patient was negative for both DQA1*0501 and DQB1*0201 alleles.

引用

页码：38 / 39

页数：2

共 4 条

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LUNDIN KEA, 1990, J IMMUNOL, V145, P136

[2]

MORELLINI M, 1988, DIS MARKERS, V6, P23

[3] EVIDENCE FOR A PRIMARY ASSOCIATION OF CELIAC-DISEASE TO A PARTICULAR HLA-DQ ALPHA-BETA HETERODIMER [J].