REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL-GROWTH .3. STRUCTURES OF REVEROMYCIN-A, REVEROMYCIN-B, REVEROMYCIN-C AND REVEROMYCIN-D

被引：67

作者：

KOSHINO, H ^{[1
]}

TAKAHASHI, H ^{[1
]}

OSADA, H ^{[1
]}

ISONO, K ^{[1
]}

机构：

[1] SNOW BRAND MILK PROD CO LTD,LIFE SCI RES INST,ISHIBASHI,TOCHIGI 32905,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 09期

关键词：

D O I：

10.7164/antibiotics.45.1420

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Reveromycins A, B, C and D are new group inhibitors of the mitogenic activity of epidermal growth factor (EGF), produced by Streptomyces sp. Reveromycins are novel polyketide type antibiotics which have two terminal carboxylic groups, a spiroketal, a succinate and a varied side chain in the molecule. Determination of their structures by chemical and spectroscopic methods, in particular NMR studies, is described.

引用

页码：1420 / 1427

页数：8

共 5 条

[1] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].

BAX, A ;

SUMMERS, MF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094

[2] THE C-13-NMR SPECTRA OF POLYETHER ANTIBIOTICS AND SOME EMPIRICAL RULES FOR STRUCTURAL STUDIES OF POLYETHER ANTIBIOTICS [J].

SETO, H ;

OTAKE, N .

HETEROCYCLES, 1982, 17 :555-580

[3] REVEROMYCINS, NEW INHIBITORS OF EUKARYOTIC CELL-GROWTH .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION AND PHYSICOCHEMICAL PROPERTIES [J].

TAKAHASHI, H ;

OSADA, H ;

KOSHINO, H ;

KUDO, T ;

AMANO, S ;

SHIMIZU, S ;

YOSHIHAMA, M ;

ISONO, K .

JOURNAL OF ANTIBIOTICS, 1992, 45 (09) :1409-1413

[4]

TGAKAHASHI H, 1992, J ANTIBIOT, V45, P1414

[5]

WESTLEY JW, 1983, POLYETHER ANTIBIOTIC, V2, P355

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