NEW APPLICATIONS OF THE MITSUNOBU REACTION IN THE SYNTHESIS OF C-2 N-METHYL CARBAPENEMS

被引：20

作者：

ARNOULD, JC

LANDIER, F

PASQUET, MJ

机构：

[1] ICI Pharma, Centre de recherches

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 47期

关键词：

MITSUNOBU REACTION; CARBAPENEM; AMINATION; AMIDE FORMATION; AMINO HETEROCYCLE ALKYLATION;

D O I：

10.1016/S0040-4039(00)60855-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-acyl amides and N-acylamino heterocycles can be reacted regioselectively with C-2 hydroxymethyl carbapenems under Mitsunobu conditions:synthesis of amides, exocyclic alkylation of amino heterocycles and transformation into 2-aminomethyl carbapenems are reported.

引用

页码：7133 / 7136

页数：4

共 23 条

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