ANTIBACTERIAL TRITERPENOID ACIDS FROM DILLENIA-PAPUANA

被引：35

作者：

NICK, A ^{[1
]}

WRIGHT, AD ^{[1
]}

STICHER, O ^{[1
]}

RALI, T ^{[1
]}

机构：

[1] ETH ZURICH,DEPT PHARM,CH-8057 ZURICH,SWITZERLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 09期

关键词：

D O I：

10.1021/np50111a009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new oleanene-type triterpenoids, dillenic acids A [1], B [2], and C [3], and two known compounds, 3-oxoolean-1,12-dien-30-oic acid [4] (a new natural product) and the lupene derivative betulinaldehyde, have been isolated from the Papua New guinean medicinal plant Dillenia papuana. The structures of the new compounds were elucidated as 2 alpha-hydroxy-3-oxoolean-12-en-30-oic acid, 2-oxo-3 beta-hydroxyolean-12-en-30-oic acid and 1 alpha-hydroxy-3-oxoolean-12-en-30-oic acid. The H-1- and C-13-nmr data of all new compounds were assigned unambiguously using a variety of 2D nmr experiments including H-1-H-1-COSY, HMQC, HMBC, and NOESY experiments. Of these compounds, 1-4 showed antibacterial activities against Bacillus subtilis, Escherichia coli, and Micrococcus luteus.

引用

页码：1245 / 1250

页数：6

共 20 条

[1]

BALUN L, 1988, International Journal of Crude Drug Research, V26, P51

[2]

BARAN JS, 1971, J MED CHEM, V17, P184

[3] MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .32. PENTACYCLIC TRITERPENES [J].