EUPENIFELDIN, A NOVEL CYTOTOXIC BISTROPOLONE FROM EUPENICILLIUM-BREFELDIANUM

被引:57
作者
MAYERL, F
GAO, Q
HUANG, S
KLOHR, SE
MATSON, JA
GUSTAVSON, DR
PIRNIK, DM
BERRY, RL
FAIRCHILD, C
ROSE, WC
机构
[1] Pharmaceutical Research Institute, Wallingford, Connecticut 06492, Bristol-Myers Squibb Company
关键词
D O I
10.7164/antibiotics.46.1082
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-1 16 cell line and has in vivo antitumor activity in the P388 leukemia model.
引用
收藏
页码:1082 / 1088
页数:7
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