UNCONVENTIONAL NUCLEOTIDE ANALOGUES .1. N9-PURINYL ALPHA-AMINO ACIDS

被引：43

作者：

NOLLET, AJH

HUTING, CM

PANDIT, UK

机构：

[1] Laboratory of Organic Chemistry, University of Amsterdam, Amsterdam

来源：

TETRAHEDRON | 1969年 / 25卷 / 24期

关键词：

D O I：

10.1016/S0040-4020(01)83104-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 6-chloropurine (3), 2,6-dichloropurine (4) and 2-amino-6-chloropurine (5) with t-butyl α-benzyloxycarbonylamido-γ-bromobutyrate (6b) gave high yields of the corresponding N6-alkylated products (10a, 11a, 12a). Suitable transformations of the latter led to the formation of 4-(N9-purinyl)-α-aminobutyricacids correspon xanthine (23). © 1969.

引用

页码：5971 / &

共 37 条

[1]

ANDERSON B, 1961, J BIOL CHEM, V236, P455

[2]

Baker BR, 1967, DESIGN ACTIVE SITE D

[3]

BEAMAN AG, 1963, J ORG CHEM, V28, P2310

[4] CYTO-ACTIVE AMINO-ACIDS AND PEPTIDES .2. RESOLUTION OF PARA-SUBSTITUTED PHENYLALANINES AND SYNTHESIS OF PARA-DI-(2-CHLOROETHYL)AMINO-DL-PHENYL [BETA-C-14]ALANINE [J].