COMPARISON OF SCHISTOSOMICIDAL ACTIVITY OF XANTHENONES AND 4-METHYL-3-CHLOROANILINES AND THEIR HYDROXYMETHYL ANALOGS IN SWISS MICE AND SYRIAN HAMSTERS INFECTED WITH SCHISTOSOMA MANSONI

被引：5

作者：

BERBERIAN, DA

DENNIS, EW

FREELE, H

ROSI, D

LEWIS, TR

LORENZ, R

ARCHER, S

机构：

[1] Sterling-Winthrop Research Institute, Rensselaer

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1021/jm00304a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The schistosomicidal activity of a number of xanthenones, 4-methyl-3-chloroanilines, and their hydroxylated derivatives were tested against Schistosoma mansoni. It was demonstrated that hydroxylation enhanced schistosomicidal activity one- to sixfold in the mouse and two- to 33-fold in the hamster. © 1969, American Chemical Society. All rights reserved.

引用

页码：607 / +

页数：1

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