Acute Behavioral Effects of Triazolam and Caffeine, Alone and in Combination, in Humans

被引：14

作者：

Rush, Craig R. ^{[1
,2
]}

Higgins, Stephen T. ^{[1
,2
]}

Hughes, John R. ^{[1
,2
]}

Bickel, Warren K. ^{[1
,2
]}

机构：

[1] Univ Vermont, Dept Psychiat, 38 Fletcher Pl, Burlington, VT 05401 USA

[2] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

来源：

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY | 1994年 / 2卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1037/1064-1297.2.3.211

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The acute behavioral effects of triazolam (0, 0.375, and 0.75 mg/70 kg) and caffeine (0, 250, and 500 mg/70 kg), alone and in combination, were assessed in 9 male volunteers. Ss received all possible dose combinations according to a Latin square design. Triazolam administered alone dose dependently disrupted learning and performance on the Repeated Acquisition and Performance procedure and the Digit Symbol Substitution Test and increased S ratings of sedation. Caffeine administered alone did not significantly affect learning or performance measures, but it did dose dependently increase S ratings of drug strength. Caffeine significantly attenuated triazolam-induced decrements in learning and performance. Consistent with effects on learning and performance, caffeine offset triazolam-induced increases in S ratings of sedation. Combining caffeine and triazolam did not significantly alter increases in S ratings of drug strength observed with caffeine alone. These effects are qualitatively similar to those observed with other benzodiazepines (e.g., lorazepam) and document a high degree of consistency in the behavioral pharmacology of benzodiazepine-caffeine combinations in humans.

引用

页码：211 / 222

页数：12

共 33 条

[1] THE EFFECTS OF DIAZEPAM AND TRIAZOLAM ON REPEATED ACQUISITION AND PERFORMANCE OF RESPONSE SEQUENCES WITH AN OBSERVING RESPONSE [J].