ELECTROCHEMICAL AND IONTOPHORETIC STUDIES OF HUMAN SKIN

被引：73

作者：

DENUZZIO, JD

BERNER, B

机构：

[1] Ciba-Geigy Corporation, Basic Pharmaceutics Research, Ardsley, NY 10502

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 11卷 / 1-3期

关键词：

impedance spectroscopy; ion selectivity; ion transport; iontophoresis; transdermal drug delivery;

D O I：

10.1016/0168-3659(90)90124-C

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Impedance spectroscopy, constant-current iontophoresis, and potentiometry are used to characterize ionic transport in human epidermis in vitro. A resistor (solution resistance) in series with a parallel combination of resistance and capacitance (membrane) is an equivalent circuit for epidermis. Membrane conduction appears to occur in free solution within a restricted volume fraction. The flux of tryptophanamide HCl across epidermis is linear with current, and the efficiency varies from 1 to 5% among skin samples. Electro-osmosis appears to be at best a second-order effect. Iontophoresis is reversible except for a long time tail in the impedance. Within the alkali metals, human epidermis is cation selective, but not size selective. © 1990.

引用

页码：105 / 112

页数：8

共 21 条

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