APPLICATION OF INTRINSIC-VISCOSITY AND INTERACTION CONSTANT AS A FORMULATION TOOL FOR FILM COATING .2. STUDIES ON DIFFERENT GRADES OF ETHYL CELLULOSE IN ORGANIC-SOLVENT SYSTEMS

被引：6

作者：

ARWIDSSON, H ^{[1
]}

NICKLASSON, M ^{[1
]}

机构：

[1] ASTRA RES CTR AB,SODERTALJE,SWEDEN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 58卷 / 01期

关键词：

Controlled release; Dilute solution properties; Ethyl cellulose; Interaction constant; Intrinsic viscosity; Organic solvent system;

D O I：

10.1016/0378-5173(90)90289-G

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Intrinsic viscosity, [η], and interaction constant, k', have been determined for ethyl cellulose 7, 22, and 50 cps in 5 different organic solvent systems in order to select suitable systems for a coating process applicable for a wide range of ethyl cellulose grades of different molecular weight. The results indicate that methylene chloride/ethanol (60:40, % w/w) is an advantageous solvent system for each of the polymer grades studied. The interaction constant shows corresponding values for the different ethyl cellulose grades in each solvent system studied, apparently independent of molecular weight. Thus, k' was found to be more generally applicable than [η] when searching for a solvent system with high-solvent power for ethyl cellulose since [η] is a function of the molecular weight. © 1990.

引用

页码：73 / 77

页数：5

共 11 条

[1]

THE INFLUENCE OF SOLVENT COMPOSITION ON THE SPECIFIC VISCOSITIES OF POLYMER SOLUTIONS [J].