EFFECTS OF CAFFEINE ON MATERNAL REPAIR SYSTEMS IN DROSOPHILA-MELANOGASTER - CONCENTRATION-DEPENDENT REVERSALS OF THE EFFECTS OF CAFFEINE ON CHROMOSOME LOSS AND AUTOSOME-AUTOSOME TRANSLOCATIONS INDUCED BY X-RAYS IN THE PATERNAL GENOME

被引：8

作者：

OSGOOD, C ^{[1
]}

ZIMMERING, S ^{[1
]}

机构：

[1] BROWN UNIV,DIV BIOL & MED,PROVIDENCE,RI 02912

来源：

MUTATION RESEARCH | 1979年 / 63卷 / 01期

关键词：

D O I：

10.1016/0027-5107(79)90105-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Drosophila melanogaster females were treated with 1% caffeine, mated with X-rayed males and the frequencies of induced sex-chromosome loss, translocations between the major autosomes and between the Y-chromosome and the major autosomes determined. In a reversal of the results obtained previously with 0.2% caffeine by Mendelson and Sobels, treatment of females with 1% caffeine led to a decrease in sex-chromosome loss, confirming preliminary data of Zimmering and Osgood and an increase in autosome-autosome translocations. It is suggested that the higher concentration of caffeine inhibits replication permitting more time available for chromosomes-type restitutions by means of caffeine-insensitive repair mechanisms. In contrast with results for autosome-autosome translocation, the frequency of Y-autosome translocations was depressed below controls suggesting an isolation (by any one of several means) of Y-chromosome breaks from those in the autosomes. © 1979.

引用

页码：79 / 86

页数：8

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