CHARACTERIZATION OF SOMATOSTATIN RELEASE FROM THE PANCREAS - ROLE OF POTASSIUM

被引：16

作者：

HERMANSEN, K

CHRISTENSEN, SE

ORSKOV, H

机构：

[1] Second University Clinic of Internal Medicine, Kommunehospitalet, DK-8000, Aarhus C

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1979年 / 39卷 / 08期

关键词：

Atropine; Calcium; Glucose; Parasympathetic nervous system; Perfused pancreas; Potassium; Propranolol; Radioimmunoassay; Somatostatin release; Sympathetic nervous system;

D O I：

10.3109/00365517909108162

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of potassium on somatostatin secretion from the isolated perfused canine pancreas was studied. Potassium stimulated dose-dependent somatostatin release in a monophasic response pattern. The effect of potassium was abolished in the absence of calcium. Perfusion of 1 μmiol/1 atropine and 1 μmol/l propranolol was without effect on the potassium induced somatostatin release. The results suggest that the stimulatory effect of potassium on somatostatin release is secondary to increases in calcium influx into the D cell. The sympathetic and parasympathetic nerve endings in the pancreas are apparently not involved in the potassium mediated secretory processes. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：717 / 722

页数：6

共 30 条

[1]

ALBERTI KGM, 1973, LANCET, V2, P1299

[2] EFFECT OF GLUCOSE ON K+ HANDLING BY PANCREATIC-ISLETS [J].