SYNTHESIS OF A NEW BRIDGED DIAMINE 3,6-DIAZABICYCLO[3.2.0]HEPTANE - APPLICATIONS TO THE SYNTHESIS OF QUINOLONE ANTIBACTERIALS

被引：19

作者：

JACQUET, JP

BOUZARD, D

KIECHEL, JR

REMUZON, P

机构：

[1] Pharmaceutical Research Institute, Bristol-Myers Squibb, 77422 Marne-la-Vallée

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)74273-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diprotected 3,6-diazabicyclo [3.2.0] heptane has been prepared by an highly efficient process. Selective deprotection, followed by condensation with 7-halogenoquinolones led to the napththyridones 10 and 13 and the quinolone 14.

引用

页码：1565 / 1568

页数：4

共 5 条

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[4] FLUORONAPHTHYRIDINES AND FLUOROQUINOLONES AS ANTIBACTERIAL AGENTS .3. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NEW 1-(1,1-DIMETHYL-2-FLUOROETHYL), 1-[1-METHYL-1-(FLUOROMETHYL)-2-FLUOROETHYL], AND 1-[1,1-(DIFLUOROMETHYL)-2-FLUOROETHYL] SUBSTITUTED DERIVATIVES
REMUZON, P
BOUZARD, D
DICESARE, P
ESSIZ, M
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KIECHEL, JR
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KESSLER, RE
FUNGTOMC, J
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 29 - 37
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