SYNTHESIS OF A NEW BRIDGED DIAMINE 3,6-DIAZABICYCLO[3.2.0]HEPTANE - APPLICATIONS TO THE SYNTHESIS OF QUINOLONE ANTIBACTERIALS

被引:19
作者
JACQUET, JP
BOUZARD, D
KIECHEL, JR
REMUZON, P
机构
[1] Pharmaceutical Research Institute, Bristol-Myers Squibb, 77422 Marne-la-Vallée
关键词
D O I
10.1016/S0040-4039(00)74273-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Diprotected 3,6-diazabicyclo [3.2.0] heptane has been prepared by an highly efficient process. Selective deprotection, followed by condensation with 7-halogenoquinolones led to the napththyridones 10 and 13 and the quinolone 14.
引用
收藏
页码:1565 / 1568
页数:4
相关论文
共 5 条
  • [1] FLUORONAPHTHYRIDINES AND QUINOLONES AS ANTIBACTERIAL AGENTS .2. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NEW 1-TERT-BUTYL 7-SUBSTITUTED DERIVATIVES
    BOUZARD, D
    DICESARE, P
    ESSIZ, M
    JACQUET, JP
    KIECHEL, JR
    REMUZON, P
    WEBER, A
    OKI, T
    MASUYOSHI, M
    KESSLER, RE
    FUNGTOMC, J
    DESIDERIO, J
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) : 1344 - 1352
  • [2] BOUZARD D, 1989, J MED CHEM, V32, P357
  • [3] PYRROLIDINEDIOLS . 1-SUBSTITUTED 3-HYDROXYMETHYL-4-HYDROXYPYRROLIDINES AND DERIVATIVES
    JAEGER, E
    BIEL, JH
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (03) : 740 - &
  • [4] FLUORONAPHTHYRIDINES AND FLUOROQUINOLONES AS ANTIBACTERIAL AGENTS .3. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NEW 1-(1,1-DIMETHYL-2-FLUOROETHYL), 1-[1-METHYL-1-(FLUOROMETHYL)-2-FLUOROETHYL], AND 1-[1,1-(DIFLUOROMETHYL)-2-FLUOROETHYL] SUBSTITUTED DERIVATIVES
    REMUZON, P
    BOUZARD, D
    DICESARE, P
    ESSIZ, M
    JACQUET, JP
    KIECHEL, JR
    LEDOUSSAL, B
    KESSLER, RE
    FUNGTOMC, J
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 29 - 37
  • [5] 8956673