TISSUE ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY IN SPONTANEOUSLY HYPERTENSIVE HAMSTERS

被引：20

作者：

RUBINSTEIN, I

HOUMSSE, M

DAVIS, RG

VISHWANATHA, JK

机构：

[1] UNIV NEBRASKA, MED CTR, DEPT PHYSIOL & BIOPHYS, OMAHA, NE 68198 USA

[2] UNIV NEBRASKA, MED CTR, DEPT BIOCHEM, OMAHA, NE 68198 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)80306-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to measure angiotensin I-converting activity in heart, kidney, lung and cheek pouch tissue homogenates of spontaneously hypertensive and normotensive hamsters. We also determined inhibitor sensitivity and the effects of chloride anion concentration on kidney angiotensin I-converting activity in these animals. We found no significant differences in angiotensin I-converting activity between hypertensive and normotensive hamsters in all tissues tested. Inhibitor sensitivity of kidney angiotensin I-converting activity with captopril and lisonopril was similar in both groups. Finally, kidney angiotensin I-converting activity increased significantly in both groups as chloride anion concentration in the assay buffer increased. Substituting chloride anion for citrate abrogated the increase in angiotensin I-converting enzyme activity. © 1992 Academic Press, Inc.

引用

页码：1117 / 1123

页数：7

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