CP-99,711 - A NONPEPTIDE GLUCAGON RECEPTOR ANTAGONIST

被引：36

作者：

COLLINS, JL ^{[1
]}

DAMBEK, PJ ^{[1
]}

GOLDSTEIN, SW ^{[1
]}

FARACI, WS ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)80587-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

CP-99,711, identified in a screening program, displaces [I-125]-glucagon from its rat liver receptor. We describe here the synthesis of this compound and its characterization as a functional glucagon receptor antagonist.

引用

页码：915 / 918

页数：4

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