THE EFFECT OF VIGABATRIN ON COGNITIVE FUNCTION AND MOOD

被引：6

作者：

DIJKSTRA, JB ^{[1
]}

MCGUIRE, AM ^{[1
]}

TRIMBLE, MR ^{[1
]}

机构：

[1] INST NEUROL, DEPT NEUROL, QUEEN SQ, LONDON WC1N 3BG, ENGLAND

来源：

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | 1992年 / 7卷 / 05期

关键词：

ANTIEPILEPTIC DRUGS; VIGABATRIN; COGNITIVE FUNCTION; MOOD;

D O I：

10.1002/hup.470070504

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive function and mood have been assessed in nine patients started on vigabatrin as additional therapy to their regular anticonvulsants. Psychological tests were given at baseline (S1) and at 4 weeks (S2) after starting treatment. A comparison group of nine patients on stable therapy was tested at the same time intervals. In particular, tasks with minimal or no motor components were used. Mood was rated with the Beck Depression Inventory. The vigabatrin group scored significantly higher on a task of attention and concentration at S2. This was not related to change of seizure frequency or serum levels of other anticonvulsants. No effects were observed on mood.

引用

页码：319 / 323

页数：5

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