SYNTHESIS OF NEW PENEM DITHIOCARBAMATES

被引：9

作者：

ALTAMURA, M ^{[1
]}

GIANNOTTI, D ^{[1
]}

PERROTTA, E ^{[1
]}

SBRACI, P ^{[1
]}

PESTELLINI, V ^{[1
]}

ARCAMONE, FM ^{[1
]}

SATTA, G ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, I-00168 ROME, ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

PENEMS; BETA-LACTAM ANTIBIOTICS; DITHIOCARBAMATE; CATECHOL; ANTIBACTERIALS;

D O I：

10.1016/S0960-894X(01)80918-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Penem dithiocarbamates 10 were synthesized from the alcohol 6, in high yields and favourable ratio between the penem and the undesired penam isomers. In vitro antibacterial activity showed a dependence on polarity and steric hindrance of the side chain at C-2. Best results were obtained with the piperazino derivatives 10 l-n, while catechol 10 p did not show the expected improvements in anti-pseudomonal activity.

引用

页码：2159 / 2164

页数：6

共 20 条

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