MORPHINE INDUCES C-FOS AND JUNB IN STRIATUM AND NUCLEUS-ACCUMBENS VIA D-1 AND N-METHYL-D-ASPARTATE RECEPTORS

被引：156

作者：

LIU, JL ^{[1
]}

NICKOLENKO, J ^{[1
]}

SHARP, FR ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR, SAN FRANCISCO, CA 94121 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 18期

关键词：

IMMEDIATE EARLY GENES; BASAL GANGLIA; OPIOID; DRUG ABUSE; DOPAMINE;

D O I：

10.1073/pnas.91.18.8537

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Morphine induced the c-fos and junB immediate early genes in neurons of the medial and ventral striatum and nucleus accumbens. Induction of c-fos and junB mRNA and Fos protein was blocked by naloxone, the D-1 dopamine (DA) receptor antagonists SCH23390 and SCH39166, and the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK801. SCH23390 attenuated morphine induction of AP-1 binding in striatum, suggesting that c-fos and junB contribute to AP-1 binding. SCH23390 and MK801 did not block morphine induction of c-fos and junB in septum. Since the morphine induction of c-fos and junB in striatum and nucleus accumbens (NA) was similar to that observed with cocaine and amphetamine, these data support current concepts that limbic striatum and NA are among the brain regions that mediate drug abuse. Furthermore, since DA and NMDA receptors may mediate opiate reward and opiate induction of c-fos and junB, the DA/NMDA regulation of c-fos and junB and their target genes may produce long-term changes in the striatal and NA circuits that contribute to opiate drug abuse.

引用

页码：8537 / 8541

页数：5

共 80 条

[1] ENDOGENOUS OPIOIDS - BIOLOGY AND FUNCTION [J].