SOLID-PHASE SYNTHESIS OF A SELF-COMPLEMENTARY (ANTIPARALLEL) CHIRAL PEPTIDIC NUCLEIC-ACID STRAND

被引：36

作者：

LENZI, A

REGINATO, G

TADDEI, M

TRIFILIEFF, E

机构：

[1] UNIV FLORENCE,DIPARTIMENTO CHIM ORGAN UGO SCHIFF,I-50121 FLORENCE,ITALY

[2] CNR,CTR CHIM COMPOSTI ETEROCICLICI & LORO APPLICAZ,I-50121 FLORENCE,ITALY

[3] CNRS,CTR NEUROCHIM,CHIM ORGAN SUBST NAT LAB,F-67084 STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 10期

关键词：

D O I：

10.1016/0040-4039(95)00053-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis (Boc protocol) of a new chiral peptidic nucleic acid formed exclusively by alpha-amino acids is described. The product showed a defined T-m suggesting the possibility of a DNA-like self-aggregation in solution

引用

页码：1717 / 1718

页数：2

共 5 条

[1] PEPTIDE NUCLEIC-ACIDS (PNA) - OLIGONUCLEOTIDE ANALOGS WITH AN ACHIRAL PEPTIDE BACKBONE [J].

EGHOLM, M ;

BUCHARDT, O ;

NIELSEN, PE ;

BERG, RH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (05) :1895-1897

[2] RENIN SUBSTRATES .2. RAPID SOLID-PHASE SYNTHESIS OF THE RATINE SEQUENCE TETRADECAPEPTIDE USING BOP REAGENT [J].

LENGUYEN, D ;

HEITZ, A ;

CASTRO, B .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1987, (09) :1915-1919

[3] SYNTHESIS OF N-BOC-ALPHA-AMINO ACIDS WITH NUCLEOBASE RESIDUES AS BUILDING-BLOCKS FOR THE PREPARATION OF CHIRAL PNA (PEPTIDIC NUCLEIC-ACIDS) [J].

LENZI, A ;

REGINATO, G ;

TADDEI, M .

TETRAHEDRON LETTERS, 1995, 36 (10) :1713-1716

[4] PEPTIDE ANALOGS OF DNA INCORPORATING NUCLEOBASE-ALA-PRO SUBUNITS [J].

LEWIS, I .

TETRAHEDRON LETTERS, 1993, 34 (36) :5697-5700

[5] DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID [J].

WITTUNG, P ;

NIELSEN, PE ;

BUCHARDT, O ;

EGHOLM, M ;

NORDEN, B .

NATURE, 1994, 368 (6471) :561-563

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