FURADAN-C14 METABOLISM IN A LACTATING COW

Furadan (2,3-dihydro-2,2-dimethyl-7-benzofuranyl-N-methylcarbamate) administered orally to a cow was altered chemically by oxidation of the number 3 carbon and of the N-methyl group, hydrolysis of the ester linkage, and by conjugation of metabolites containing a hydroxyl group. Carbamate metabolites in the milk were the 3-hydroxy, 3-keto, and 3-hydroxy-N-hydroxymethyl derivatives of Furadan. These materials were present in both the free and conjugated forms. Conjugated 2,3-dihydro-2,2-dimethyl-3-keto-7-hydroxybenzofuran was the major hydrolytic product of Furadan in the milk. The same metabolites also were components of the cow urine and/or feces. Data indicate that of a single oral dose of Furadan fed to a cow, approximately 0.2% would be eliminated in the milk, 0.7% in the feces, and 94% in the urine. © 1968, American Chemical Society. All rights reserved.