SYNTHESIS OF GLUTAMATE RECEPTOR ANTAGONIST PHILANTHOTOXIN-433 (PHTX-433) AND ITS ANALOGS

被引：59

作者：

GOODNOW, R ^{[1
]}

KONNO, K ^{[1
]}

NIWA, M ^{[1
]}

KALLIMOPOULOS, T ^{[1
]}

BUKOWNIK, R ^{[1
]}

LENARES, D ^{[1
]}

NAKANISHI, K ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

TETRAHEDRON | 1990年 / 46卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4020(01)85463-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the non-competative glutamate receptor inhibitor, philanthotoxin 433 (PhTX-433) is described. Furthermore, two synthetic routes are described for the preparation of a variety of structural analogs. © 1990.

引用

页码：3267 / 3286

页数：20

共 13 条

[1] STRUCTURES AND BIOLOGICAL-ACTIVITIES OF 3 SYNAPTIC ANTAGONISTS FROM ORB WEAVER SPIDER VENOM [J].

ADAMS, ME ;

CARNEY, RL ;

ENDERLIN, FE ;

FU, ET ;

JAREMA, MA ;

LI, JP ;

MILLER, CA ;

SCHOOLEY, DA ;

SHAPIRO, MJ ;

VENEMA, VJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) :678-683

[2] CHEMICAL CHARACTERIZATION OF SPIDER TOXIN, JS']JSTX AND NSTX [J].

ARAMAKI, Y ;

YASUHARA, T ;

HIGASHIJIMA, T ;

YOSHIOKA, M ;

MIWA, A ;

KAWAI, N ;

NAKAJIMA, T .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1986, 62 (09) :359-362

[3] EXCITATORY AMINO-ACIDS IN THE BRAIN - FOCUS ON NMDA RECEPTORS [J].

COTMAN, CW ;

IVERSEN, LL .

TRENDS IN NEUROSCIENCES, 1987, 10 (07) :263-265

[4] STRUCTURE AND SYNTHESIS OF A POTENT GLUTAMATE RECEPTOR ANTAGONIST IN WASP VENOM [J].

ELDEFRAWI, AT ;

ELDEFRAWI, ME ;

KONNO, K ;

MANSOUR, NA ;

NAKANISHI, K ;

OLTZ, E ;

USHERWOOD, PNR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4910-4913

[5]

GRISHIN EV, 1986, BIOORG KHIM+, V12, P1121

[6] SPIDER TOXINS AS TOOLS FOR DISSECTING ELEMENTS OF EXCITATORY AMINO-ACID TRANSMISSION [J].

JACKSON, H ;

USHERWOOD, PNR .

TRENDS IN NEUROSCIENCES, 1988, 11 (06) :278-283

[7]

Kenny P T, 1989, Rapid Commun Mass Spectrom, V3, P295, DOI 10.1002/rcm.1290030906

[8]

PIEK T, 1985, NEUROTOXICOLOGY, V6, P251

[9] PHILANTHOTOXINS - A REVIEW OF THE DIVERSITY OF ACTIONS ON SYNAPTIC TRANSMISSION [J].

PIEK, T ;

DUNBAR, SJ ;

KITS, KS ;

VANMARLE, J ;

VANWILGENBURG, H .

PESTICIDE SCIENCE, 1985, 16 (05) :488-494

[10] ARTHROPOD VENOMS AS TOOLS FOR THE STUDY OF NEUROMUSCULAR-TRANSMISSION [J].

PIEK, T .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1981, 68 (01) :75-84

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