FLAVINS AS POTENTIAL ANTIMALARIALS .2. 3-METHYL-10-(SUBSTITUTED-PHENYL)FLAVINS

被引：23

作者：

COWDEN, WB

HALLADAY, PK

CUNNINGHAM, RB

HUNT, NH

CLARK, IA

机构：

[1] Division of Virology and Cellular Pathology, John Curtin School of Medical Research, Canberra, A.C.T.

[2] Division of Virology and Cellular Pathology, Statistics, The Australian National University, Canberra, A.C.T.

[3] Department of Pathology, Sydney University, Sydney

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 06期

关键词：

D O I：

10.1021/jm00110a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 3-methyl-10-(substituted-phenyl)flavins was prepared and tested for antimalarial activity against the lethal parasite Plasmodium vinckei in mice. Several of these analogues were found to be effective antimalarial agents. A quantitative structure-activity relationship study was undertaken with 44 analogues and no satisfactory relationship could be established.

引用

页码：1818 / 1822

页数：5

共 13 条

[1]

ARIENS EJ, 1971, DRUG DESIGN, V1, P101

[2] FLAVIN ANALOGS WITH ANTIMALARIAL ACTIVITY AS GLUTATHIONE-REDUCTASE INHIBITORS [J].