RECOMBINANT GLOBULINS - NOVEL RESEARCH TOOLS AND POSSIBLE PHARMACEUTICALS

被引：16

作者：

HOLLENBAUGH, D

CHALUPNY, NJ

ARUFFO, A

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 02期

关键词：

D O I：

10.1016/0952-7915(92)90017-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A novel approach to the study of proteins is the construction of chimeras consisting of a target protein fused to an immunoglobulin constant domain. These recombinant globulins have been used in the identification of ligand-receptor pairs, determination of functional consequences of receptor engagement, the elucidation of structural domains necessary for ligand binding, and as potential therapeutic agents.

引用

页码：216 / 219

页数：4

共 23 条

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