BIOCHEMICAL-MECHANISM OF LIGHT ADAPTATION IN VERTEBRATE PHOTORECEPTORS

被引:27
作者
KOCH, KW
机构
[1] Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich, W-5170 Jülich
关键词
D O I
10.1016/0968-0004(92)90442-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vertebrate photoreceptors can adjust their sensitivity to a wide range of light intensities spanning several orders of magnitude, the phenomenon of which is called light adaptation. Electrophysiological and biochemical studies have revealed that calcium can serve as an intracellular transmitter of light adaptation under the control of cGMP metabolism. After illumination, the cytoplasmic calcium concentration of a photoreceptor decreases, which in turn strongly activates photoreceptor guanylate cyclase. This calcium-dependent effect is mediated by a novel calcium-binding protein (recoverin) and leads to the restoration of the depleted cGMP pool after illumination.
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页码:307 / 311
页数:5
相关论文
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